Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy

摘要: Introduction: Despite epilepsies being between the oldest and most studied neurological diseases, new treatment remains an unmet need of scientific research due to high percentage refractory patients. Several studies have identified suitable anti-seizure targets. Glutamate activation α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) long ago been as targets for development anti seizure drugs. Areas covered: Here, we describe: i) AMPARs' structure their involvement role during seizures in epilepsy ii) efficacy AMPAR antagonists preclinical models epilepsy. Expert opinion: The physiological pathological CNS recently gained attention considering recent status epilepticus marketing perampanel. drugs represents a major challenge both clinical Th...