Lifespan in captive baboons is heritable

摘要: Abstract The effects of aging are evident in multiple organ systems, tissues, cell types, and molecules; all complex phenotypes affected by shared unique environmental factors genes, which makes identifying the role genetics human difficult. Researchers have used yeast, nematodes, fruit flies, mice to search for genes that influence process. Given phylogenetic distance anatomic physiologic dissimilarities these organisms from humans, directly extrapolating results our species is problematic. However, nonhuman primates a high degree genetic, similarity with humans and, thus, they may assist detection, characterization, identification genetic influences on aging. Our goal demonstrate variation lifespan, surrogate measure aging, can be detected primate species. Using variance component analysis, heritability age at death was estimated 0.23±0.08 ( P =0.0003) 674 baboons Southwest Foundation Biomedical Research (SFBR). This research demonstrates lifespan under partial control. findings, we believe baboon has potential as model