Ebolavirus comparative genomics.

摘要: The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine dynamics of genome, we compare more than 100 currently available ebolavirus genomes to each other and viral genomes. Based on oligomer frequency analysis, family Filoviridae forms a distinct group from all sequenced All filovirus date encode proteins with similar functions gene order, although there considerable divergence sequences between three genera Ebolavirus, Cuevavirus Marburgvirus within Filoviridae. Whereas are quite (multiple same strain often identical), variation most common intergenic regions specific areas genes encoding glycoprotein (GP), nucleoprotein (NP) polymerase (L). We predict that could contain epitope-binding sites, which might be good vaccine targets. This information, combined glycosylation sites experimentally determined epitopes, can identify promising development therapeutic strategies. This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 U.S. Department Energy. United States Government retains publisher, accepting article publication, acknowledges non-exclusive, paid-up, irrevocable, world-wide license publish or reproduce published form manuscript, allow others do so, purposes. Energy will provide public access these results federally sponsored research accordance DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).