Evidence for Pre- to Postsynaptic Mismatch of the Cardiac Sympathetic Nervous System in Ischemic Congestive Heart Failure
作者： J. H. Caldwell , J. M. Link , W. C. Levy , J. E. Poole , J. R. Stratton
DOI: 10.2967/JNUMED.107.044339
关键词:
摘要: Pre- and postsynaptic cardiac sympathetic function is altered in ischemic congestive heart failure (CHF). Whether there a presynaptic-to-postsynaptic mismatch or whether related to adverse events unknown. Methods: In 13 patients with CHF 25 aged-matched healthy volunteers, presynaptic was measured by PET of 11 Cmeta-hydroxyephedrine ( C-mHED), norepinephrine (NE) analog.Postsynapticfunction, b-adrenergicreceptor(BAR)density (B9max), imaging C-CGP12177. Myocardial blood flow (MBF) 15 O-water. Each analyzed both globally regionally, excluding infarcted regions, score, defined as the ratio B9 NE uptake (PSnt), used indicate post- function. Results: Global regional MBF not different between subjects. The global measure PSnt lower (0.32 6 0.34) than that subjects (0.81 0.33, P , 0.0001) all 12 regions. B9tended be (10.0 66.4 pmol/mL vs. 13.4 64.2,P 50.056)and score (B9max:PSnt) significantly greater (50.3 50.7 19.3 9.7, 5 0.005) also After 1.5 y follow-up, 4 individuals had an outcome (CHF death, new recurrent sudden progressive leading transplantation). Three scores . 3 times without outcome. Conclusion: Mismatch pre- left ventricular present severe may more marked those outcomes.
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