ABO(H) blood groups and vascular disease: a systematic review and meta-analysis.
作者： O. WU , N. BAYOUMI , M. A. VICKERS , P. CLARK
DOI: 10.1111/J.1538-7836.2007.02818.X
关键词:
摘要: Background Associations between vascular disease and ABO(H) blood groups have a long history, but no consensus exists regarding its magnitude significance, or whether it relates to all disorders equally. An accurate calculation of risk would allow direct assessment the effects non-O status on thrombosis are predicted by effect von Willebrand factor/FVIII levels. Methods results We conducted systematic review meta-analysis studies reporting associations with groups. This gave pooled odds ratios 1.25 [95% confidence interval (CI) 1.14-1.36] for myocardial infarction (MI), 1.03 (95% CI 0.89-1.19) angina, 1.45 1.35-1.56) peripheral disease, 1.14 1.01-1.27) cerebral ischemia arterial origin, 1.79 1.56 2.05) venous thromboembolism (VTE). However, restriction prospective MI only did not confirm association (OR 1.01; 95% 0.84-1.23), although these may failed capture early-onset disease. For VTE, using combined group OO/A(2)A(2)/A(2)O as index, combination A(1)A(1)/A(1)B/BB an OR 2.44 1.79-3.33) A(1)O/ BO/A(2)B 2.11 1.66-2.68). Conclusions study confirms historical impression linkage some status. Although similar those factor levels, further work is required assess prospectively refine reducing O(H) antigen expression thrombosis. particularly A(1)A(1), A(1)B, BB constitute significant proportion population attributable fraction there be role more widespread adoption typing in testing strategies.
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