SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis

摘要: Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much known about the upstream inflammatory mechanisms provoking fibrosis downstream potential tissue remodeling. However, less transcriptional regulation in vivo governing fibrotic matrix deposition by myofibroblasts. This gap in understanding has hampered molecular predictions of disease severity clinical progression restricted targets antifibrotic drug development. In this study, we show prevalence SOX9 biopsies from patients with correlated accurately predicted toward cirrhosis. Inactivation Sox9 mice protected against both parenchymal biliary fibrosis, improved function ameliorated inflammation. was mechanosignaling factor, YAP1. These data demonstrate role open way transcription factor its dependent pathways as new diagnostic, prognostic, therapeutic fibrosis.