Hyperglycaemia-induced miR-301a promotes cell proliferation by repressing p21 and Smad4 in prostate cancer.

摘要: Abstract Hyperglycaemia promotes the development of Prostate cancer (PCa). However, roles miRNAs in this disease process and underlying mechanisms are largely unknown. In study, we recruited 391 PCa patients China found that with high level blood glucose (≥100 mg/dL) trended to have Gleason score (GS ≥ 7). miRNA-301a levels were significantly higher prostate than normal tissues. or treatment induced miR-301a expression tissues cell lines. suppressed p21 Smad4, subsequently promoted G1/S cycle transition proliferation in vitro xenograft growth nude mice in vivo. Furthermore, knockdown Smad4 mimicked effects overexpression. Restoration smad4 could interrupt Importantly, inhibition severely blocked glucose-induced both These results revealed a novel molecular link between hyperglycaemia PCa. The plays an important role hyperglycaemia-associated growth, represents therapeutic target for