Inhibition of Chondrocyte and Synovial Cell Death After Exposure to Commonly Used Anesthetics Chondrocyte Apoptosis After Anesthetics
作者： Allison J. Rao , Tyler R. Johnston , Alex H.S. Harris , R. Lane Smith , John G. Costouros
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摘要: Background:An intra-articular injection of local anesthetics is a common procedure for diagnostic and therapeutic purposes. It has been shown that these agents are toxic to articular cartilage synovial tissue in dose- time-dependent fashion, some cases, they may lead postarthroscopic glenohumeral chondrolysis (PAGCL). However, the role apoptosis cell death still unclear, potential inhibition minimizing chondrocyte not reported.Purpose:(1) To quantify degree apoptotic chondrocytes cells exposed anesthetics, (2) determine whether caspase could reduce death.Study Design:Controlled laboratory study.Methods:Human were expanded vitro normal saline, 0.5% bupivacaine, ropivacaine, 1% lidocaine, or 1:1000 epinephrine 90 minutes. Apoptosis was then detected at 1, 3, 5, 7 days after exposure using te...
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