The Role of RNA-Protein Interactions in Intracellular Targeting

摘要: The eukaryotic cell is characterised by the possession of membrane bound subcellular organelles, which nucleus generally regarded as most important, being responsible for control and regulation intra- intercellular activities. In order to construct it necessary that nuclear components, especially proteins are made in cytoplasm, segregate properly into correct compartment. mechanisms molecules targetted have been discussed two recent reviews (De Robertis, 1983, Dingwall, 1985) subject several contributions this volume. Other decisions be taken during eg. development or differentiation influenced information exchange between some probably involving movement regulatory e.g. developmental determinants (Coriklin, 1905, Gurdon, 1977) cytoplasm nucleus. One mechanism such a change intracellular location can achieved paper. Two examples macromolecules their following RNA-protein interaction will discussed. first example exclusion from 5S RNA its with TFIIIA, transcription factor gene expression. second translocation protein components U snRNPs binding snRNA.