The emerging roles of forkhead box (Fox) proteins in cancer
作者： Stephen S. Myatt , Eric W. -F. Lam
DOI: 10.1038/NRC2223
关键词:
摘要: Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control wide spectrum biological processes. As consequence, loss or gain Fox function can alter cell fate and promote tumorigenesis as well cancer progression. Here we discuss the evidence that deregulation family transcription factors has crucial role in development progression cancer, evaluate emerging direct indirect targets for therapeutic intervention, biomarkers predicting monitoring treatment responses.
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