Evidence suggesting that high intake of fluoride provokes nephrolithiasis in tribal populations

摘要: The present study was designed to evaluate the role of fluoride in urolithiasis humans. Two areas were selected for this purpose, a endemic area (EA) and non-endemic (NEA). prevalence uroliathiasis 4.6 times higher EA than NEA. Furthermore, almost double subjects with fluorosis without area. No relationship observed between duration fluorosis. levels drinking water ranged from 3.5 4.9 ppm excreted more fluoride. A comparison normal (NS) NEA revealed that tend have slightly mean serum thiobarbituric acid reactive substance (TBAR) excrete oxalate their counterparts. urinary stone formers (SF) two showed similar tendency, though again difference not significant. Citrate excretion SF EA, but had significantly lower levels. Urinary stones patients fluoride, calcium those patients. In vitro studies suggested did influence heterogonous mineralization oxalate. conclusion, data suggest vivo may behave as mild promoter formation by (a) insoluble (b) increasing (c) mildly oxidative burden.