Low aromatase activity and gene expression in human fetal testes.
作者： Juha Tapanainen , Raimo Voutilainen , Robert B. Jaffe
DOI: 10.1016/0022-4731(89)90350-6
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摘要: Because of previous indications that estradiol (E2) plays a role in the regulation testicular testosterone (T) production some species, E2 and aromatase gene expression human fetal testes were investigated. Testicular minces from 14 fetuses (fetal age 15-23 weeks) incubated with without 200 ng/ml highly purified hCG, T was measured by RIA. Basal high at 15-18 weeks gestation decreased thereafter. Estradiol low all testes. Aromatase mRNA (P-450 arom messenger ribonucleic acid) not detectable tissues when studied Northern dot blot techniques. Placenta liver expressed mRNA, but ovary contained only miniscule amounts. HCG significantly stimulated both older (19-23 weeks), youngest (15-18 did increase after hCG stimulation. These results indicate activity are very findings suggest may play major fetus.
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