Correlation between the presence of high‐risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer

摘要: Infection by high-risk human papillomaviruses (HPVs) is considered to be the central cause of invasive cervical cancer. Previously reported studies have shown that Id genes regulate cell invasion and metastasis in several carcinomas including In order investigate correlation between HPVs cancer, presence their association with gene expression was examined using PCR methods tissue microarray analyses a cohort 44 cancer patients from Syria. This study showed were present 42 samples (95%) represent cancers most frequent HPV types Syrian women 33, 16, 18, 45, 52, 58, 35, 51 31. Furthermore, E6 oncoprotein found correlate overexpression Id-1, but not Id-2, Id-3 or Id-4 majority samples. These data suggest can enhance progression through Id-1 regulation.