Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy.
作者： Gerald M. Fuller , Gene P. Siegal , Minghui Wang , David T. Curiel , Simon A. Jones
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摘要: In this study, we report that an interleukin-6 (IL-6)-inducible E1A-substituting activity can be exploited for the production of infectious adenoviral particles during infection with E1A-deleted adenovirus (Ad) Ad5dl312. The basal level complementation increased by 1.5 log induction HepG2 cells recombinant human IL-6. Additionally, IL-6-inducible complement E1A deletion in other cancer cell lines to render them Ad producer on IL-6, although efficiency varies between lines. Ad5dl312 replicate in, produce cytotoxic effect, and kill tumor without addition exogenous IL-6 context possessing autocrine arc, such as ovarian cells. contrast, normal mesothelial isolated from peritoneum lining do not support replication Ad5dl312, even presence These results suggest could used a agent selectively responsive or arc.
aacrjournals.org参考文章(65)
D. Poubouridis, P. B. Sehgal, S. S. Tabibzadeh, L. T. May, Interleukin-6 immunoreactivity in human tumors. American Journal of Pathology. ,vol. 135, pp. 427- 433 ,(1989)
L Sachs, J Lotem, Control of programmed cell death in normal and leukemic cells: new implications for therapy Blood. ,vol. 82, pp. 15- 21 ,(1993) , 10.1182/BLOOD.V82.1.15.BLOODJOURNAL82115
Chester M. Southam, Alice E. Moore, Induced virus infections in man by the Egypt isolates of West Nile virus. American Journal of Tropical Medicine and Hygiene. ,vol. 3, pp. 19- 50 ,(1954) , 10.4269/AJTMH.1954.3.19
Robert L. Martuza, Herbert J. Manz, Samuel D. Rabkin, Takahito Yazaki, Treatment of Human Malignant Meningiomas by G207, a Replication-competent Multimutated Herpes Simplex Virus 1 Cancer Research. ,vol. 55, pp. 4752- 4756 ,(1995)
Eric R. Schuur, Daniel R. Henderson, Ronald Rodriguez, Jonathan W. Simons, Gail A. Henderson, Ho Yeong Lim, Prostate Attenuated Replication Competent Adenovirus (ARCA) CN706: A Selective Cytotoxic for Prostate-specific Antigen-positive Prostate Cancer Cells Cancer Research. ,vol. 57, pp. 2559- 2563 ,(1997)
Otsuka T, Okuno Y, Takahashi M, Yamanishi K, Tanioka T, Uemura F, Asada T, Fukui O, Matsumoto K, Aoyama H, Wada A, Studies on the use of mumps virus for treatment of human cancer. Biken's Journal. ,vol. 21, pp. 37- 49 ,(1978)
Twiggs L, Mohanraj D, Carson Lf, Moradi M, Ramakrishnan S, Olson Mc, Li By, Human ovarian epithelial cancer cells cultured in Vitro express both interleukin 1α and β genes Cancer Research. ,vol. 52, pp. 2248- 2252 ,(1992)
Chung Lee, Masato Okamoto, Ryoichi Oyasu, Interleukin-6 as a Paracrine and Autocrine Growth Factor in Human Prostatic Carcinoma Cells in Vitro Cancer Research. ,vol. 57, pp. 141- 146 ,(1997)
E Bridge, G Ketner, Redundant control of adenovirus late gene expression by early region 4. Journal of Virology. ,vol. 63, pp. 631- 638 ,(1989) , 10.1128/JVI.63.2.631-638.1989
Shizuo Akira, Tetsuya Taga, Tadamitsu Kishimoto, Interleukin-6 in biology and medicine Advances in Immunology. ,vol. 54, pp. 1- 78 ,(1993) , 10.1016/S0065-2776(08)60532-5