The Limbic System and Stress Ulcers

摘要: Our working hypothesis, over the past decade, has been that limbic system modulates stress ulcer susceptibility1,2. It was largely based on early reports in literature linked (in a vague kind of way) this interconnected brain structures to development so-called “psychosomatic” disorders. In 1949 MacLean3, elaborating Papez4 theory emotions, proposed might represent primitive “visceral brain”, responsible for psychosomatic diseases. Much evidence case from patients with temporal lobe epilepsies. Patients uncinate fits were described, whose feelings terror also sometimes associated visceral auras, i.e., various gastric and intestinal symptoms, ranging epigastric uneasiness, chewing movements grinding teeth, hunger frequent defecation urination. Correspondingly, data animal studies indicated parts be involved emotional behavior. Kluver Bucy5 had reported monkeys bilateral lobectomies became tame docile, showed collection symptoms which labelled “psychic blindness”, displayed “oral tendencies”, engaged bizarre sexual activities. appeared could no longer discriminate between potentially dangerous objects useful them. One interpretation these is lesions disconnected sensory inputs appropriate, adaptive behaviors. Later experiments many effects radical traced damage amygdala6. These findings lead proposal amygdala connects responses, recognition particular situation may threatening organism7.