Clot friction variation with fibrin content; implications for resistance to thrombectomy.

摘要: Background Despite significant advancements in the procedural efficacy of mechanical thrombectomy patients with ischemic stroke recent years, there still remains a portion population that does not achieve good recanalization. The reasons for this may be varied. We hypothesized static friction between clot and vessel, or catheter wall might contribute to difficulty removing clot. Objective To determine if is relationship composition resistance sliding (friction) which removal. Methods As can vary significantly, we investigated five different types order measure their respective frictional properties. do this, custom-made testing apparatus was created, consisting various replaceable low-friction surfaces on clots could placed. surface then gradually tilted until began slide; angle at occurred related coefficient clots. experiment repeated bovine aortic confirm results. Results found fibrin-rich ( 20%. This result confirmed by repeating as representation interaction arterial wall. Conclusions properties were content ratio fibrin red blood cells. Future imaging techniques show cell help us predict ‘stickiness’