Nitric oxide synthase in the human pituitary gland.

摘要: Abstract Nitric oxide (NO) is generated by the NO synthase family of isozymes, which present in many mammalian cells. The constitutive isozymes generate NO, acts via signal transduction mechanisms regulation functions including vascular tone and blood pressure, inducible mediate immunological cytotoxic cytostatic effects. To determine whether has a role anterior pituitary cell function, immunohistochemistry situ hybridization analyses were used to study expression normal neoplastic human tissues. Brain was localized secretory folliculo-stellate cells posterior pituitary. Pituitary adenomas had higher levels brain protein mRNA compared with pituitaries. Endothelial also endothelial Immunoblotting studies antibodies detected slowly migrating approximately 155-kd band more rapidly 90-kd 60-kd bands. synthase, but not macrophage immunoblotting studies, confirming immunohistochemical observations. These findings indicate that expressed tissues increased non-neoplastic suggest may play regulatory hormone secretion