Oral hyposensitization in nickel allergy

摘要: In two controlled studies, each including 24 patients with contact allergy to nickel, different protocols were designed in an attempt diminish the patients' hypersensitivity by oral administration of antigen. With doses 5.0 mg nickel sulfate taken once a week for 6 weeks, but not 0.5 daily, degree was significantly lowered, measured as patch test reactions before and after administration.