Azobenzene C‐Nucleosides for Photocontrolled Hybridization of DNA at Room Temperature
作者： Thomas Goldau , Keiji Murayama , Clara Brieke , Hiroyuki Asanuma , Alexander Heckel
关键词:
摘要: Herein, we report the reversible light-regulated destabilization of DNA duplexes by using azobenzene C-nucleoside photoswitches. The incorporation two different residues into and their photoswitching properties are described. These new demonstrate a photoinduced effect comparable to widely applied D-threoninol-linked switch, which is currently benchmark. photoswitches presented herein show excellent efficiencies in - even at room temperature superior commonly used azobenzene-based nucleic acid In addition, these exhibit high thermal stability fatigue resistance, thus rendering them one most efficient candidates for regulation duplex with light.
sci-hub.se 参考文章(68)
Padmabati Mondal, Mithun Biswas, Thomas Goldau, Alexander Heckel, Irene Burghardt, In Search of an Efficient Photoswitch for Functional RNA: Design Principles from a Microscopic Analysis of Azobenzene-linker-RNA Dynamics with Different Linkers. Journal of Physical Chemistry B. ,vol. 119, pp. 11275- 11286 ,(2015) , 10.1021/ACS.JPCB.5B03118
Xingguo Liang, Hiroyuki Asanuma, Hiromu Kashida, Akitsugu Takasu, Taiichi Sakamoto, Gota Kawai, Makoto Komiyama, NMR study on the photoresponsive DNA tethering an azobenzene. Assignment of the absolute configuration of two diastereomers and structure determination of their duplexes in the trans-form. Journal of the American Chemical Society. ,vol. 125, pp. 16408- 16415 ,(2003) , 10.1021/JA037248J
Shohei Mori, Kunihiko Morihiro, Satoshi Obika, C5-azobenzene-substituted 2'-deoxyuridine-containing oligodeoxynucleotides for photo-switching hybridization. Molecules. ,vol. 19, pp. 5109- 5118 ,(2014) , 10.3390/MOLECULES19045109
Thorben Cordes, Cord Elsner, Teja T. Herzog, Christian Hoppmann, Torsten Schadendorf, Wolfram Summerer, Karola Rück-Braun, Wolfgang Zinth, Ultrafast Hemithioindigo-based peptide-switches Chemical Physics. ,vol. 358, pp. 103- 110 ,(2009) , 10.1016/J.CHEMPHYS.2008.12.027
Hiroyuki Asanuma, Xingguo Liang, Hidenori Nishioka, Daijiro Matsunaga, Mingzhe Liu, Makoto Komiyama, Synthesis of azobenzene-tethered DNA for reversible photo-regulation of DNA functions: hybridization and transcription. Nature Protocols. ,vol. 2, pp. 203- 212 ,(2007) , 10.1038/NPROT.2006.465
Hiroyuki Asanuma, Kenji Shirasuka, Takayuki Yoshida, Tohru Takarada, Xingguo Liang, Makoto Komiyama, Spiropyran as a Regulator of DNA Hybridization with Reversed Switching Mode to That of Azobenzene Chemistry Letters. ,vol. 2001, pp. 108- 109 ,(2001) , 10.1246/CL.2001.108
Hiroyuki Asanuma, Xingguo Liang, Makoto Komiyama, meta-Aminoazobenzene as a thermo-insensitive photo-regulator of DNA-duplex formation Tetrahedron Letters. ,vol. 41, pp. 1055- 1058 ,(2000) , 10.1016/S0040-4039(99)02233-9
Wesley R. Browne, Ben L. Feringa, Making molecular machines work Nature Nanotechnology. ,vol. 1, pp. 25- 35 ,(2006) , 10.1038/NNANO.2006.45
Björn Heinz, Stephan Malkmus, Stefan Laimgruber, Steffen Dietrich, Christine Schulz, Karola Rück-Braun, Markus Braun, Wolfgang Zinth, Peter Gilch, Comparing a photoinduced pericyclic ring opening and closure: differences in the excited state pathways. Journal of the American Chemical Society. ,vol. 129, pp. 8577- 8584 ,(2007) , 10.1021/JA071396I
Cem Özçoban, Thomas Halbritter, Sabrina Steinwand, Lisa-Marie Herzig, Jörg Kohl-Landgraf, Noushin Askari, Florian Groher, Boris Fürtig, Christian Richter, Harald Schwalbe, Beatrix Suess, Josef Wachtveitl, Alexander Heckel, Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications. Organic Letters. ,vol. 17, pp. 1517- 1520 ,(2015) , 10.1021/ACS.ORGLETT.5B00397