Risk of malignancy in women with systemic lupus erythematosus.

摘要: Objective. To estimate the risk of malignancy in a cohort patients with systemic lupus erythematosus (SLE) from university medical center. Methods. The consisted who were residents Allegheny County and seen at University Pittsburgh, 1981-91. Cases cancer identified by postal survey review records. expected number malignancies estimated age, sex, race adjusted census incidence data County. Standardized ratios 95 % confidence intervals for all cancers calculated. Results. Six (2.7%) observed 219 during observation interval (1981-91) after first visit Pittsburgh. was 4.42. standardized ratio 1.36 (95 0.50-2.96). frequency not increased small had received immunosuppressive drugs before diagnosis cancer. Non-Hodgkin's lymphoma occurred one patient, also Sjogren's syndrome, patient entry into this study treated FK-506 following renal transplant. No bladder interval. Conclusion. overall center mean followup 5.2 yrs. Longterm multicenter effort is needed to refine estimates lupus.