Enzymatic regulation of the prostaglandin response in a human model of inflammation
作者： B. F. McAdam , G. A. Fitzgerald
DOI: 10.1007/978-94-011-5386-7_13
关键词:
摘要: Prostaglandins (PG) are potent biological mediators of thrombosis and the inflammatory response1,2. Prostaglandin endoperoxide H synthase, also referred to as cyclooxygenase (COX), is a bisfunctional protein, which catalyses first committed step in formation PG thromboxanes by sequential cyclooxygenation peroxidation arachidonic acid (AA) PGH2 3,4. then converted specific PGs distinct cell synthases or isomerases. Mammalian cells contain two isoforms this enzyme, COX-1 COX-2, encoded separate genes, but they structurally homologous have similar kinetic properties5–7.
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