Impaired Leukocyte Function in Patients with Poorly Controlled Diabetes

摘要: In order to assess the influence of poor diabetes control on function leukocytes, polymorphonuclear leukocytes (PMN's) from patients with poorly controlled but nonketotic disease were studied before and after therapy. Before treatment, phagocytosis was significantly reduced (p < .001) and, consequently, rate killing test organism (type 25 pneumococcus) decreased .01). Following antidiabetes therapy improved significantly; while microbicidal rates also improved, they remained less than values .01). Serum untreated diabetics uniformly granulocytes; serum controls by diabetic PMN's, restored normal in only half patients. This transferable inhibitory effect hyperglycemic granulocytes abolished dilution, reproduced isosmotic addition glucose. These studies suggest that (1) PMN may be impaired during periods control, as has been shown previously ketoacidosis, (2) hyperglycemia or a closely related factor contribute defect.