Pulmonary functional and morphological damage after exposure to tripoli dust.

摘要: Abstract Tripoli is a microcrystalline siliceous rock used to polish metals and precious stones. Its inhalation has been associated with increased prevalence of breathing complaints pneumoconiosis. However, its acute human exposure not so far studied. We aimed at evaluating the putative mechanical, morphological, biochemical inflammatory lung damage in mice acutely exposed dust. BALB/c were randomly assigned 2 groups: In control group (CTRL, n = 6) animals received intratracheally (i.t.) 0.9% NaCl (50 μl), while (TRIP, n = 15) 20 mg powder diluted 50 μL saline i.t. The experiments done 15 days later. TRIP showed higher pulmonary mechanical impedance, polymorphonuclear cells, TNF-α, IL1-β IL-6 than CTRL. presented granulomatous nodules containing collagenous fibers that occupied 35% tissue area. conclusion, dust triggered important lungs if found workers could trigger severe illness.