Erythropoietin activity in the serum of beta thalassemic patients.

摘要: Serum erythropoietic activity was determined in 32 patients with beta thalassemia major and intermedia. Quantitation performed by an vitro bioassay using rabbit erythroid precursor cells (CFU-E) either colony assay or 3H-thymidine uptake. 20 polytransfused beta-thalassemic had (mean 89.3 +/- 36 milliunits/ml) which not significantly different (p greater than 0.2) from normal individuals (51.3 milliunits/ml). 12 untransfused intermedia were found to have comparable serum 0.01). These levels much lower those aplastic anemia who a degree of anemia. We shown that the low EPO thalassemic due experimental conditions (excess ferritin, transferrin) nor specific inhibitors appearing this disease. No correlation between sex other clinical parameters such as severity anemia, splenectomy, iron chelation transfusion therapy. 4 young children (1-2 yr age) studied high ranging 661 5793 milliunits/ml--significantly same age. It is suggested, therefore, decrease erythropoietin develops during course