A highly active and stable imidazolidine-bridged N,O-donor ligand for efficient palladium catalyzed Suzuki–Miyaura reactions in water

摘要: We have used the sterically hindered N,O-donor ligand 1,4-bis(2-hydroxy-3,5-di-tert-butyl-benzyl)-imidazolidine with various Pd salts as a catalyst for Suzuki reaction. This system exhibited excellent catalytic activity in reactions of arylboronic acids aryl halides, including iodides, bromides and activated chlorides, using aqueous methanol solvent under mild conditions. The can be reused once without significant loss activity. hindered imidazolidine-bridged mixed nitrogen, oxygen 1 was efficient Pd-catalyzed involving chlorides acid K2CO3 base high or moisture stable palladium complexes maybe distribute to bulky tert-butyl effect.