High risk of HIV-related mortality is associated with selenium deficiency

摘要: To determine the independent contribution of specific immunologic and nutritional factors on survival in HIV-1 disease, CD4 cell count, antiretroviral treatment, plasma levels vitamins A, E, B6, B12 minerals selenium zinc were considered relation to relative risk for HIV-related mortality. Immune parameters nutrients known affect immune function evaluated at 6-month intervals 125 HIV-1-seropositive drug-using men women Miami, FL, over 3.5 years. A total 21 HIV-1-infected participants died causes during 3.5-year longitudinal study. Subclinical malnutrition (i.e., overly low prealbumin, [RR] = 4.01, p < 0.007), deficiency vitamin (RR 3.23, 0.03), 8.33, 0.009), 2.29.1, 0.04), 19.9, 0.0001) time, but not zidovudine shown each be associated with HIV-1-related mortality counts <200/mm3 baseline, time. When all that could survival, including nutrient deficiencies jointly, only time 0.69, 0.04) 10.8, 0.002) significantly These results indicate is an predictor those infection.