Evidence for the Scarr-Rowe effect on genetic expressivity in a large US sample.

摘要: Using the Continuous Parameter Estimation Method (CPEM), a large genotyped sample of population Wisconsin, USA (the Wisconsin Longitudinal Study, N=8,509) is examined for evidence Scarr-Rowe effect, an adverse gene x environment (GxE) interaction that reduces heritability IQ among those with low socioeconomic status. This method allows differential expressivity polygenic scores predictive both educational attainment and (EA3) on phenotype to be operationalized throughout full range these variables. Utilizing parental SES factor-weighted composite as measure childhood SES, effect was found, i.e. genetic EA3 increased increasing (β=.064, p=3.82x10-9, df=8508). The found male female samples separately (β(males)=.051, p=.002, df=4062; β(females)=.076, p=1.76x10-7, df=4445) there were no significant sex differences in magnitudes, however. effects furthermore robust removing outlying values SES.