Nanoscale-Based Delivery of RNAi for Cancer Therapy
作者： Ronit Satchi-Fainaro , Galia Tiram , Anna Scomparin
DOI: 10.1007/978-3-642-36853-0_14
关键词:
摘要: The ability to detect pathways that malignant tissue depends on, combined with the specific gene-knockdown of siRNA/miRNA, may revolutionize cancer treatment. capability providing personalized care patients allows therapy be specifically tailored for each case. Several studies and nonmalignant tissues have been performed in context global protein interaction networks order find optimal targets, a list potential gene targets type patient. Nevertheless, due poor stability RNAi molecules physiological conditions its inability cross cellular membranes, vivo delivery siRNA miRNA holds great challenge remains crucial issue therapeutic success. Supramolecular carriers are often used improve physicochemical biopharmaceutical properties RNAi. Nanoscale drug systems will enable accumulation drugs tumors enhanced permeability retention (EPR) effect, release siRNA/miRNA only inside target cell. In addition, targeting moiety can increase selectivity uptake tissue. vehicles (dendrimers, nanoparticles, polyplex, lipoplex, polymeric nanoconjugates) being developed delivery. These provide an important tool exploiting full nucleic acids as agents. this chapter, we review different approaches deliver oligonucleotides vivo.
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