Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin-Induced Asthma in Mice.

摘要: Pelargonium sidoides (PS) is traditionally used to treat respiratory and gastrointestinal infections, dysmenorrhea, hepatic disorders in South Africa. Coptis Rhizoma (CR) gastroenteric disorders, cardiovascular diseases, cancer East Asia. In the present study, we intended observe possible beneficial antiasthma effects of PS CR on ovalbumin- (OVA-) induced asthma C57BL/6J mice. Asthma mice was by OVA sensitization subsequent boosting. PS + CR (300 1,000 mg/kg; PO) or dexamethasone (IP) administered once a day for 16 days. The changes body weight gains, lung weights gross inspections, total differential cell counts leukocytes bronchoalveolar lavage fluid (BALF), serum OVA-specific immunoglobulin E (OVA-sIgE) levels, interleukin-4 (IL-4) IL-5 levels BALF tissue homogenate, IL-4 mRNA homogenates were analyzed with histopathology: mean alveolar surface area (ASA), septal thickness, numbers inflammatory cells, mast eosinophils infiltrated regions, respectively. Significant increases weights, BALF, OVA-sIgE homogenate observed control as compared those intact control. addition, showed significant decrease ASA regions. However, these allergic asthmatic significantly inhibited dose-dependent manner. this OVA-induced through anti-inflammatory antiallergic activities. Therefore, it expected that have enough potential new therapeutic agent an ingredient medicinal various diseases including asthma.