Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice.

摘要: The role of biological sex in short-term and long-term outcome after traumatic brain injury (TBI) remains controversial. observation that exogenous female steroids (progesterone estrogen) reduce coupled with a small number clinical studies showing smaller women suggest may play from TBI. We used the controlled cortical impact (CCI) model TBI mice to test hypothesis CCI, would demonstrate less than male mice, related protective endogenous steroids. Indeed, adult females exhibit histological protection (3.7 ± 0.5 mm3) compared (6.8 ± 0.6 mm3), lacked (ovex) showed increased intact females. Consistent histology, sensorimotor deficits measured as reduced contralateral limb use were most pronounced (31.9 ± 6.9% use) 12.7 ± 3.8% reduction mice. Ovex exhibited behavioral similar males (31.5 ± 3.9% use). demonstrated microglial activation relative both peri-injury cortex reticular thalamic nucleus. also astrogliosis comparison cortex. These data indicate sensitivity acute neuroinflammation contribute observed