Diverse forms of a receptor for acidic and basic fibroblast growth factors.

作者: D E Johnson , P L Lee , J Lu , L T Williams

DOI: 10.1128/MCB.10.9.4728

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摘要: We recently reported the isolation of a chicken cDNA clone encoding basic fibroblast growth factor (FGF) receptor that has three immunoglobulinlike domains in extracellular region. have now identified four unique human clones previously unknown FGF variants which contain only two domains. Two encode membrane-spanning receptors, and putative secreted forms. Both three- two-immunoglobulinlike-domain forms mediate biological responsiveness to acidic FGF. Thus, first domain three-domain form may function other than binding

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