Investigation of the Catalytic Mechanism of a Synthetic DNAzyme with Protein-like Functionality: An RNaseA Mimic?

作者: Jason M. Thomas , Jung-Ki Yoon , David M. Perrin

DOI: 10.1021/JA900125N

关键词:

摘要: … 2D-anatomy resembling the minimal hammerhead ribozyme and 10-23 DNAzyme; therefore, 9 25 -… Indeed, toward these ends, we have recently reported a self-cleaving DNAzyme that …

参考文章(111)
E Murphy, C Steenbergen, L A Levy, B Raju, R E London, Cytosolic free magnesium levels in ischemic rat heart. Journal of Biological Chemistry. ,vol. 264, pp. 5622- 5627 ,(1989) , 10.1016/S0021-9258(18)83593-1
K. Barbara Schowen, Richard L. Schowen, [29] Solvent isotope effects on enzyme systems Methods in Enzymology. ,vol. 87, pp. 551- 606 ,(1982) , 10.1016/S0076-6879(82)87031-6
Tuomas Lönnberg, Harri Lönnberg, Chemical models for ribozyme action. Current Opinion in Chemical Biology. ,vol. 9, pp. 665- 673 ,(2005) , 10.1016/J.CBPA.2005.10.004
E. Murphy, C. C. Freudenrich, L. A. Levy, R. E. London, M. Lieberman, Monitoring cytosolic free magnesium in cultured chicken heart cells by use of the fluorescent indicator Furaptra Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 2981- 2984 ,(1989) , 10.1073/PNAS.86.8.2981
Alexei A. Neverov, Zhong-Lin Lu, Christopher I. Maxwell, Mark F. Mohamed, Christopher J. White, Josephine S. W. Tsang, R. Stan Brown, Combination of a Dinuclear Zn2+ Complex and a Medium Effect Exerts a 1012-Fold Rate Enhancement of Cleavage of an RNA and DNA Model System Journal of the American Chemical Society. ,vol. 128, pp. 16398- 16405 ,(2006) , 10.1021/JA0651714
Peter M. J. Burgers, Fritz Eckstein, Diastereomers of 5'-O-adenosyl 3'-O-uridyl phosphorothioate: chemical synthesis and enzymatic properties. Biochemistry. ,vol. 18, pp. 592- 596 ,(1979) , 10.1021/BI00571A007
Lene Petersen, Martijn C. de Koning, Petra van Kuik-Romeijn, Jimmy Weterings, Christine J. Pol, Gerard Platenburg, Mark Overhand, Gijsbert A. van der Marel, Jacques H. van Boom, Synthesis and in vitro evaluation of PNA-peptide-DETA conjugates as potential cell penetrating artificial ribonucleases. Bioconjugate Chemistry. ,vol. 15, pp. 576- 582 ,(2004) , 10.1021/BC034219P
R. Breslow, R. Xu, Recognition and catalysis in nucleic acid chemistry. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 1201- 1207 ,(1993) , 10.1073/PNAS.90.4.1201
N.G. Beloglazova, V.N. Sil'nikov, M.A. Zenkova, V.V. Vlassov, Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic FEBS Letters. ,vol. 481, pp. 277- 280 ,(2000) , 10.1016/S0014-5793(00)02029-9