Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis.
作者： Brian G. Weinshenker , Dean M. Wingerchuk , Sandra Vukusic , Linda Linbo , Sean J. Pittock
DOI: 10.1002/ANA.20770
关键词:
摘要: Objective We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse or development optic neuritis. Methods Prospective study patients with LETM who were tested for presence NMO-IgG. Results Eleven 29 (37.9%) seropositive after a first attack spanning three more vertebral segments on magnetic resonance imaging. Of 23 followed up 1 year, none 14 seronegative experienced developed neuritis. 9 patients, 5 second event: 4 (44%) recurrent and (11%) neuritis (p = 0.004). Interpretation LETM represents an inaugural limited form NMO in high proportion patients. The 40% are NMO-IgG risk relapse. Ann Neurol 2006
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