Cyclodextrin/dextran based hydrogels prepared by cross-linking with sodium trimetaphosphate.
作者： Véronique Wintgens , Cédric Lorthioir , Pierre Dubot , Bernard Sébille , Catherine Amiel
DOI: 10.1016/J.CARBPOL.2015.06.038
关键词:
摘要: Novel βCD-based hydrogels have been synthesized using sodium trimetaphosphate (STMP) as non-toxic reagent. Straightforward mixing of βCD with dextran and STMP in basic aqueous media led to incorporating chains, phosphate groups units. The characterized by swelling measurements, XPS (31)P NMR. ratio was correlated the content phosphated groups, which give a polyelectrolyte character these hydrogels. significant rise increase has attributed decrease number phosphate-based crosslinks, units playing role dangling ends tridimensional network. Their loading capacity their release properties investigated for methylene blue benzophenone order demonstrate potentiality drug delivery. Through different interaction mechanisms, electrostatic inclusion complex interactions, compounds are loaded efficiencies. involves deswelling, diffusion mechanisms partition equilibrium.
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