Calcium pectinate gel beads for controlled release drug delivery : I. Preparation and in vitro release studies

摘要: Calcium pectinate gel (CPG) beads of indomethacin, a poorly soluble drug, were prepared by dispersing indomethacin in solution pectin and then dropping the dispersion into calcium chloride solution. The droplets instantaneously formed gelled spheres ionotropic gelation. effect several factors such as type, presence hardening agent drug loading investigated on percentage entrapped, size distribution release from CPG beads. characteristics studied using rotating basket dissolution method. Strong spherical with narrow distributions, high yields good entrapment efficiencies could be prepared. All have significantly affected mechanism followed diffusion controlled model for an inert porous matrix. Therefore, useful carrier delivery drugs.