Autologous platelet-rich plasma for treating chronic wounds

摘要: Background Autologous platelet-rich plasma (PRP) is a treatment that contains fibrin and high concentrations of growth factors has the potential to aid wound healing. Objectives To determine whether autologous PRP promotes healing chronic wounds. Search methods We searched Cochrane Wounds Group Specialised Register (searched 15 August 2012); The Central Controlled Trials (CENTRAL) (The Library 2012, Issue 8); Ovid MEDLINE (1950 Week 1 (In-Process & Other Non-Indexed Citations, 14, EMBASE (1980 2012 32); EBSCO CINAHL (1982 10 2012) International Clinical Registry Platform (ICTRP)(accessed 22 2012). No date or language restrictions were applied. Selection criteria We included randomised controlled trials (RCTs) compared with placebo alternative treatments for any type in adults. Data collection analysis Two review authors independently assessed each study against inclusion criteria, extracted data risk bias all trials. We calculated ratio (RR) mean difference (MD) time was analysed as survival using hazard (HR). considered heterogeneity significant when I2 >75%. Main results Nine eligible RCTs included, total 325 participants whom 44% women. median number per RCT 26 (range 86). Four recruited people mixed wounds (there caused by more than one aetiology who had several aetiologies same trial), three venous leg ulcers two foot diabetes. length 12 weeks eight 40 weeks). One at low bias, studies remainder being overall unclear bias. proportion completely healed reported seven standard placebo, no statistically between groups, diabetic (RR 1.16; 95% CI 0.57 2.35), (pooled RR 1.02; 0.81 1.27; I2=0% ) 1.85; 0.76 4.51; I2=42%). area epithelialised end intervention wounds, there groups MD -1.94 cm2; -4.74 0.86; I2=47%). percentage results favour group 51.78%; 32.70 70.86; I2= 0%). Wound complications like infection necrosis RCTs, 1.08; 0.31 3.73). Adverse effects treated those not given 1.07; 0.32 3.58; I2=0%). Authors' conclusions There currently evidence suggest value treating wounds. However, current based on small most which are either Well-designed adequately powered clinical needed.