Aspects of the Animal Collagenases

摘要: Information accumulated over the past 13 years since first animal collagenase was detected (Gross and Lapiere, 1962; Lapiere Gross, 1963) indicates that collagenolysis in biological systems is accomplished by a series of enzymes one which, operating at physiologic pH temperature extracellular spaces, produces critical cleavage helical body molecule within fibril Nagai, 1965; Kang et al., 1966; Sakai 1967). This step followed or more enzyme activities which reduce polypeptide fragments to smaller peptides amino acids. We know considerably about responsible for initial attack than we do subsequent dismantling fragments. How much this latter events takes place cell has yet be determined. The possibility preliminary peptide bonds terminal nonhelical regions resulting loss intermolecular cross-linking insoluble fibrils real one, but such an activity neutral not been unequivocally detected.