Statins: under investigation for increasing bone mineral density and augmenting fracture healing.
作者： Quen Oak Tang , Gui Tong Tran , Zakareya Gamie , Simon Graham , Evaggelos Tsialogiannis
DOI: 10.1517/13543784.17.10.1435
关键词:
摘要: Background: Statins are 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors and have been shown to possess anti-lipidaemic properties effective in lowering cholesterol. Recent evidence has suggested beneficial pleiotropic effects, including that of fracture healing, alongside its widely accepted ability reduce the incidence cardiovascular disease. Objectives: A comprehensive review recent literature on effect statins bone mineral density healing. Methods: Medline/Ovid EMBASE search manual bibliography key papers, effects metabolism vitro vivo studies, as well clinical trials risk. Results/conclusions: There is robust suggest anabolic metabolism. Although patients with osteoporosis conflicting, several studies use associate...
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