Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated with pesticide chlorpyrifos exposure in rats
作者： Isaac A Adedara , Olatunde Owoeye , Ifeoluwa O Awogbindin , Babajide O Ajayi , Joao BT Rocha
DOI: 10.1016/J.CBI.2018.09.016
关键词:
摘要: Abstract Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) a simple synthetic organoselenium well reported possess antioxidant, anti-inflammatory neuroprotective effects. However, there paucity of information on the beneficial effects DPDS CPF-mediated brain injury neurobehavioural deficits. The present study investigated mechanism rats sub-chronically treated CPF alone at 5 mg/kg body weight or orally co-treated 2.5 for 35 consecutive days. Endpoint analyses using video-tracking software novel environment revealed that co-treatment significantly (p
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