A framework to evaluate the economic impact of pharmacogenomics

摘要: Introduction: Pharmacogenomics and personalized medicine promise to improve healthcare by increasing drug efficacy minimizing side effects. There may also be substantial savings realized eliminating costs associated with failed treatment. This paper describes a framework using health claims data for analyzing the potential value of pharmacogenomic testing in clinical practice. Methods: We evaluated model alternate strategies asthma patients’ from retrospective database determine cost offset. estimated likely impact hypothetical test preferred initial therapy. compared annualized per patient distributions under two strategies: all patients nonresponse genotype prior treating none. Results: In Test All strategy, more fall into lower ranges distribution. our base case (15% phenotype prevalence, US$200 test, 74% over...