Selenium at the Neural Barriers: AReview.

摘要: Selenium (Se) is known to contribute several vital physiological functions in mammals: antioxidant defense, fertility, thyroid hormone metabolism, and immune response. Growing evidence indicates the crucial role of Se Se-containing selenoproteins brain function. As for other essential trace elements, dietary needs reach effective concentrations central nervous system (CNS) exert its functions. To do so, Se-species have cross blood-brain barrier (BBB) and/or blood-cerebrospinal fluid (BCB) choroid plexus. The main interface between general circulation body CNS BBB. Endothelial cells capillaries forming so-called tight junctions are primary anatomic units BBB, mainly responsible current review focuses on transport brain, primarily including selenoprotein P/low-density lipoprotein receptor-related protein 8 (LRP8, also as apolipoprotein E receptor-2) dependent pathway, supplementary routes into via low molecular weight Se-species. Additionally, potential BCB, neurovascular unit (NVU) discussed. Finally, perspectives regarding investigating gut-brain axis outlined.