Modeling the metabolism of Penicillin-G formation

摘要: Micro-organisms have been used since many decades for the production of valuable chemicals food, pharmaceutical and bulk industries. Examples are amino acids, vitamins, antibiotics or alcohols organic acids (Table VII.1). Improvement properties has achieved using random classical mutation techniques. The development recombinant-DNA techniques, unraveling complete genomes genome wide information measurement (DNA chips) recently opened possibility precise modifications in microbial metabolism. goals such “rational metabolic engineering” “de novo” improved desirable chemical compounds. Rational engineering opens to use micro-organisms a wider scope fine chemicals. This is called “cell factory concept”. Table VII.1 Microbial processes Product Market volume (tons/yr.) Lysine 100.000 Glutamic acid 1000.000 Functional proteins 10.000 s-lactam antibiotics 45.000 Ethanol 25.000.000 Lactic acid 50.000