Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

作者: Ram Awatar Maurya , Kyoung-Ik Min , Dong-Pyo Kim

DOI: 10.1039/C3GC41226A

关键词:

摘要: An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. The techniques include: a droplet technique liquid–liquid and/or gas–liquid separation in situ generation the toxic reagent, dual channel membrane based on cheap polymeric microseparator separation, capillary microreactor carrying out cascade sequential continuous manner.

参考文章(47)
Michael Struempel, Bernd Ondruschka, Ralf Daute, Annegret Stark, Making diazomethane accessible for R&D and industry : generation and direct conversion in a continuous micro-reactor set-up Green Chemistry. ,vol. 10, pp. 41- 43 ,(2008) , 10.1039/B710554A
Alan R. Katritzky, Suoming Zhang, Yunfeng Fang, BtCH(2)TMS-assisted homologation of carboxylic acids: A safe alternative to the arndt-eistert reaction Organic Letters. ,vol. 2, pp. 3789- 3791 ,(2000) , 10.1021/OL0002370
Hannah E. Bartrum, David C. Blakemore, Christopher J. Moody, Christopher J. Hayes, Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines. Journal of Organic Chemistry. ,vol. 75, pp. 8674- 8676 ,(2010) , 10.1021/JO101783M
Phan Huy Hoang, Chi Thanh Nguyen, Jayakumar Perumal, Dong-Pyo Kim, Droplet synthesis of well-defined block copolymers using solvent-resistant microfluidic device Lab on a Chip. ,vol. 11, pp. 329- 335 ,(2011) , 10.1039/C0LC00321B
Chan Pil Park, Ram Awatar Maurya, Jang Han Lee, Dong-Pyo Kim, Efficient photosensitized oxygenations in phase contact enhanced microreactors Lab on a Chip. ,vol. 11, pp. 1941- 1945 ,(2011) , 10.1039/C1LC20071B
K. C. Basavaraju, Siddharth Sharma, Ram Awatar Maurya, Dong-Pyo Kim, Safe Use of a Toxic Compound: Heterogeneous OsO4 Catalysis in a Nanobrush Polymer Microreactor Angewandte Chemie. ,vol. 52, pp. 6735- 6738 ,(2013) , 10.1002/ANIE.201301124
Muhammad Irfan, Toma N. Glasnov, C. Oliver Kappe, Continuous Flow Ozonolysis in a Laboratory Scale Reactor Organic Letters. ,vol. 13, pp. 984- 987 ,(2011) , 10.1021/OL102984H
Jessamine Ng Lee, Cheolmin Park, George M. Whitesides, Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Analytical Chemistry. ,vol. 75, pp. 6544- 6554 ,(2003) , 10.1021/AC0346712