Synthesis, characterization, and fluorescence study of tryptone-self-assembled and Zn(II)-coordinated nanoparticles

摘要: Peptides/amino acids are biodegradable and biocompatible have been used as suitable biomaterials for many bioengineering medical applications in the last few decades. However, sometimes they show very limited intrinsic optical properties when imaging probes biological diagnostics target-based drug monitoring applications. Here we synthesized novel tryptone-self-assembled Zn(II)-coordinated nanoparticles (TZFNPs), which shifted fluorescence emission peak from ultraviolet (270 nm) of tryptone to visible wavelength (470 nm). Furthermore, coordinated with 4-chloro-7-nitrobenzofurazan (NBD-Cl), a fluorogenic reagent, signals our TZFNPs were further enhanced directly cellular environment well. We also studied fluorescent these after transferring them into intracellular space U2OS HeLa cell lines. These intrinsically bioimaging. hope will pave new way sciences clinical trials.