Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule
作者： M.I. Cordero , J.J. Rodríguez , H.A. Davies , C.J. Peddie , C. Sandi
DOI: 10.1016/J.NEUROSCIENCE.2005.03.046
关键词:
摘要: The amygdala is a brain area which plays decisive role in fear and anxiety. Since exposure to chronic stress can induce profound effects emotion cognition, plasticity specific amygdaloid nuclei response prior has been hypothesized account for stress-induced emotional alterations. In order identify may be affected under conditions we evaluated the of 21-days restraint on expression molecule implicated crucially alterations structural plasticity: polysialylated neural cell adhesion molecule. We found that molecule-immunoreactivity within amygdala, present somata neuronal processes, regional gradient with central medial showing highest levels. Our results demonstrate induced an overall reduction complex, mainly due significant decrease nuclei. data suggest these play prominent functional remodeling by stress, being potential mechanism cognitive modulation. Furthermore, finding provide first clear evidence life experiences regulate complex.
core.ac.uk
manchester.ac.uk
elsevier.com参考文章(65)
Dionysia T. Theodosis, Renée Bonhomme, Sergio Vitiello, Geneviève Rougon, Dominique A. Poulain, Cell Surface Expression of Polysialic Acid on NCAM Is a Prerequisite for Activity-Dependent Morphological Neuronal and Glial Plasticity The Journal of Neuroscience. ,vol. 19, pp. 10228- 10236 ,(1999) , 10.1523/JNEUROSCI.19-23-10228.1999
Joseph E. LeDoux, The amygdala: contributions to fear and stress Seminars in Neuroscience. ,vol. 6, pp. 231- 237 ,(1994) , 10.1006/SMNS.1994.1030
C Sandi, J.J Merino, M.I Cordero, K Touyarot, C Venero, Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1 Neuroscience. ,vol. 102, pp. 329- 339 ,(2001) , 10.1016/S0306-4522(00)00484-X
Tatsunori Seki, Yasumasa Arai, Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system Neuroscience Research. ,vol. 17, pp. 265- 290 ,(1993) , 10.1016/0168-0102(93)90111-3
Cheryl D Conrad, Donald D Macmillan Ii, Sergey Tsekhanov, Ryan L Wright, Sarah E Baran, Rita A Fuchs, Influence of chronic corticosterone and glucocorticoid receptor antagonism in the amygdala on fear conditioning. Neurobiology of Learning and Memory. ,vol. 81, pp. 185- 199 ,(2004) , 10.1016/J.NLM.2004.01.002
Raffaella Molteni, Fabio Fumagalli, Valerio Magnaghi, Mila Roceri, Massimo Gennarelli, Giorgio Racagni, Roberto C Melcangi, Marco A Riva, Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity. Brain Research Reviews. ,vol. 37, pp. 249- 258 ,(2001) , 10.1016/S0165-0173(01)00128-X
Ernest D. Kemble, D.Caroline Blanchard, Robert J. Blanchard, Ruby Takushi, Taming in wild rats following medial amygdaloid lesions Physiology & Behavior. ,vol. 32, pp. 131- 134 ,(1984) , 10.1016/0031-9384(84)90084-2
Takao Kubo, Hideaki Okatani, Yusuke Nishigori, Yukihiko Hagiwara, Ryuji Fukumori, Yoshio Goshima, Involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. Neuroscience Letters. ,vol. 354, pp. 84- 86 ,(2004) , 10.1016/J.NEULET.2003.09.061
A.M. Magarin˜os, B.S. McEwen, Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors Neuroscience. ,vol. 69, pp. 89- 98 ,(1995) , 10.1016/0306-4522(95)00259-L
Cheryl D. Conrad, Liisa A. M. Galea, Yasukazu Kuroda, Bruce S. McEwen, Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behavioral Neuroscience. ,vol. 110, pp. 1321- 1334 ,(1996) , 10.1037/0735-7044.110.6.1321