Sirtuin functions and modulation: from chemistry to the clinic.

Jeremy S. Disch, Pui Yee Ng, Robert B. Perni, Charles A. Blum, Chi B. Vu, Benzimidazoles and related analogs as sirtuin modulators ,(2009)

Han Dai, April W. Case, Thomas V. Riera, Thomas Considine, Jessica E. Lee, Yoshitomo Hamuro, Huizhen Zhao, Yong Jiang, Sharon M. Sweitzer, Beth Pietrak, Benjamin Schwartz, Charles A. Blum, Jeremy S. Disch, Richard Caldwell, Bruce Szczepankiewicz, Christopher Oalmann, Pui Yee Ng, Brian H. White, Rebecca Casaubon, Radha Narayan, Karsten Koppetsch, Francis Bourbonais, Bo Wu, Junfeng Wang, Dongming Qian, Fan Jiang, Cheney Mao, Minghui Wang, Erding Hu, Joe C. Wu, Robert B. Perni, George P. Vlasuk, James L. Ellis, Crystallographic structure of a small molecule SIRT1 activator-enzyme complex Nature Communications. ,vol. 6, pp. 7645- 7645 ,(2014) , 10.1038/NCOMMS8645

Erika S. Langsfeld, Jason M. Bodily, Laimonis A. Laimins, The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes PLOS Pathogens. ,vol. 11, pp. e1005181- ,(2015) , 10.1371/JOURNAL.PPAT.1005181

Kaushal Patel, John Sherrill, Milan Mrksich, Michael D. Scholle, Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry Journal of Biomolecular Screening. ,vol. 20, pp. 842- 848 ,(2015) , 10.1177/1087057115588512

Chong Li, Lingling Wang, Liang Zheng, Xianghong Zhan, Bin Xu, Jingting Jiang, Changping Wu, SIRT1 expression is associated with poor prognosis of lung adenocarcinoma. OncoTargets and Therapy. ,vol. 8, pp. 977- 984 ,(2015) , 10.2147/OTT.S82378

M Miyo, H Yamamoto, M Konno, H Colvin, N Nishida, J Koseki, K Kawamoto, H Ogawa, A Hamabe, M Uemura, J Nishimura, T Hata, I Takemasa, T Mizushima, Y Doki, M Mori, H Ishii, Tumour-suppressive function of SIRT4 in human colorectal cancer British Journal of Cancer. ,vol. 113, pp. 492- 499 ,(2015) , 10.1038/BJC.2015.226

P. Rangarajan, A. Karthikeyan, J. Lu, E.-A. Ling, S.T. Dheen, Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia. Neuroscience. ,vol. 311, pp. 398- 414 ,(2015) , 10.1016/J.NEUROSCIENCE.2015.10.048

Julien Lancelot, Stéphanie Caby, Florence Dubois-Abdesselem, Mathieu Vanderstraete, Jacques Trolet, Guilherme Oliveira, Franz Bracher, Manfred Jung, Raymond J. Pierce, Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets PLoS Neglected Tropical Diseases. ,vol. 7, pp. e2428- ,(2013) , 10.1371/JOURNAL.PNTD.0002428

Melissa J Wilking, Chandra K Singh, Minakshi Nihal, Mary A Ndiaye, Nihal Ahmad, Sirtuin deacetylases: A new target for melanoma management Cell Cycle. ,vol. 13, pp. 2821- 2826 ,(2014) , 10.4161/15384101.2014.949085

Sumit S. Mahajan, Michele Scian, Smitha Sripathy, Jeff Posakony, Uyen Lao, Taylor K. Loe, Vid Leko, Angel Thalhofer, Aaron D. Schuler, Antonio Bedalov, Julian A. Simon, Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. Journal of Medicinal Chemistry. ,vol. 57, pp. 3283- 3294 ,(2014) , 10.1021/JM4018064