Prognostic value of abdominal CT scanning and hepatic histopathology in patients with acute liver failure.

摘要: Acute liver failure has extremely high mortality without transplantation. We attempted to determine the value of abdominal CT scanning and biopsy in its management. A retrospective analysis patients with acute was performed; demographic, clinical, radiologic histopathologic features were noted. Over a period 13 years, 177 evaluated. The mean age 39 years 63% females. divided into three groups. Fourteen percent survived medical management (group I), 37% died II), 49% had transplantation III). Most showed diffuse low density on proportions similar Moderate large ascites not present group I but occurred 31% II 15% III. Mean hepatic volumes groups; however, 97% volume less than 1000 ml either or required Liver biopsies among spontaneous recovery I) distinguished by presence regenerative changes parenchymal necrosis 50%. These results suggest that and/or greater 50% is indicative poor prognosis. This information may assist decision making such patients, particular, regarding need for