Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma : NCI-SEER Case-Control Study

摘要: We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption vitamin B6 and methionine, dietary determinants one-carbon metabolism. Evidence has linked genetic variants involved in metabolism to NHL. investigated 30 polymorphisms 18 genes for their main effect on NHL among 1141 incident cases 949 population-based controls examined gene-nutrient interactions subgroup 386 319 who provided detailed food-frequency information. Odds ratios (ORs) 95% confidence intervals (CIs) were adjusted age, sex, race. observed decreased overall BHMT Ex8+453A>T increased CBS Ex13+41C>T, FPGS Ex15-263T>C, SHMT1 Ex12+138C>T Ex12+236C>T. Furthermore, significant limited the protective association comparing versus low Ex15-263T>C CC (OR = 0.22; CI 0.10-0.52), MTHFS IVS2-1411T>G TT/TG 0.54; 0.36-0.81), MTR Ex26-20A>G AA 0.55; 0.35-0.86) genotypes, methionine FTHFD Ex10-40G>T GG 0.63; 0.44-0.91), MTHFR Ex8-62A>C 0.13; 0.04-0.39), MTRR Ex5+136T>C TT 0.67; 0.47-0.97) genotypes. Warranting replication, our finding supports etiologic involvement lymphomagenesis.