Pseudomonas aeruginosa and lung function decline in patients with bronchiectasis

摘要: Abstract Objectives The objective of this study was to analyse lung function decline over time in bronchiectasis, along with the factors associated it. Methods Spirometry measured every year observational, prospective 849 patients from Spanish Bronchiectasis Registry (RIBRON). main outcome rate forced expiratory volume during first second (FEV1). To be included study, needed a baseline assessment and at least one subsequent assessment. FEV1 analysed using mixed-effects linear regression model adjusted for clinically significant variables. Results We recruited bronchiectasis two annual measurements (follow-up range 1–4 years). A total 2262 tests were performed (mean 2.66 per patient, 2–5). Mean 1.78 L (standard deviation (SD) 0.76; 71.3% predicted). age 69.1 (SD 15.4) years; 543 (64% women. rates –0.98% predicted/year (95% confidence interval (CI) –2.41 –0.69) –31.6 CI –44.4 –18.8) mL. faster those chronic bronchial infection by Pseudomonas aeruginosa (–1.37% (52.1 mL) vs –0.37% (–24.6 mL); p  Discussion In mL/year it older P. aeruginosa, increased number previous severe exacerbations higher value.