SYNTHESIS OF REBECCAMYCIN AND 11-DECHLOROREBECCAMYCIN

摘要: Glycosylated 7-chloroindole-3-acetamide 9, prepared in four steps and 26% yield from 7-chloroindole (1), was condensed with methyl 7-chloroindole-3-glyoxylate 11 indole-3-glyoxylate 12 to provide bisindolylmaleimides 7 8 86% 84% yield, respectively. Oxidation of followed by debenzylation provided a new approach the synthesis rebeccamycin completed for first time 11-dechlororebeccamycin.